Ivermectin B1a( —— )

Catalog No. M27454 CAS No. 71827-03-7

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ivermectin B1a
Note

Research use only, not for human use.
Brief Description

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.
Description

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.(In Vitro):Ivermectin B1a(0.3 μg/ml) is inactive, whereas in the case of the minor component, ivermectin B1b(0.3 μg/ml) produces 100% mortality of snails.
In Vitro

Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

σ1
Research Area

——
Indication

——

Chemical Information

CAS Number

71827-03-7
Formula Weight

875.09
Molecular Formula

C48H74O14
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (114.27 mM)
SMILES

CC[C@@H]([C@@H]1[C@@H](C)CC[C@]2(C[C@@H]3C[C@@H](C/C=C(C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C6CO[C@H]7[C@]\6(O)[C@H](C(O3)=O)C=C(C)[C@H]7O)O2)O1)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.

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